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KMID : 0380620090410030284
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Korean Journal of Food Science and Technology
2009 Volume.41 No. 3 p.284 ~ p.291
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Enhancement of the Antioxidant and Anticancer Activities of Berberis koreana Bark by Using a Low Temperature and High-Pressure Extraction Process
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Kim Young
Ha Ji-Hye
Jeong Myeong-Hoon
Chung Eul-Kwon
Chung Ae Ran
Kim Jin-Chul
Ahn Ju-Hee
Lee Hyeon-Yong
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Abstract
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This study was conducted to characterize the enhanced antioxidant and anticancer activities of Berberis koreanabark following a low temperature and high pressure extraction process. The results indicate that the B. koreana barkextracted as described showed a 93% increase in DPPH radical scavenging activity. Inhibition activity of xanthine oxidasewas highest by this extraction process. In addition the growth of human lung cancer cells (A549), human stomach cancercells (AGS), human breast cancer cells (MCF-7) and human liver cancer cells (Hep3B) were inhibited by 70.8%, 86.2%,84.3% and 62.5% respectively. These data indicate that this low temperature and high pressure extraction technique resultsin the efficient extraction of bioactive compounds from rigid plant materials. This process could also be combined withother techniques to improve extraction yields and identify new biologically active substances from relatively hard plants.
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KEYWORD
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Berberis koreana bark, low temperature and high-pressure extraction, antioxidant activity, anticancer activity
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